Inducible Nitric Oxide Synthase Expression in Human Colorectal Cancer
نویسندگان
چکیده
منابع مشابه
EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE GENE (iNOS) STIMULATED BY HYDROGEN PEROXIDE IN HUMAN ENDOTHELIAL CELLS
Inducible nitric oxide synthase (iNOS) gene expresses a calcium calmudolin-independent enzyme which can catalyse NO production from L-arginine. The induction of iNOS activity has been demonstrated in a wide variety of cell types under stimulation with cytokines and lipopoly saccharide (LPS). Previous studies indicated that all nitric oxide synthases (NOS) activated in human umbilical vein endot...
متن کاملRelationship between p53 mutations and inducible nitric oxide synthase expression in human colorectal cancer.
Inducible Ca-independent nitric oxide synthase (NOS), also referred to as NOS2, which is expressed in a variety of human cancers (1–4), can generate mutagenic concentrations of nitric oxide (NO) in mice (5). NOS2 is the most active isoform among the three known nitric oxide synthases (6), which also include the neuronal (NOS1) and endothelial (NOS3) isoforms. Only NOS2 is capable of producing s...
متن کاملAloe vera toxic effects: expression of inducible nitric oxide synthase (iNOS) in testis of Wistar rat
Objective(s): Nitric oxide (NO), a product of inducible nitric oxide synthase (iNOS), contributes in germ cell apoptosis. This study was aimed to evaluate the effects of Aloe vera gel (AVG) on male Wistar rat reproductive organ, serum NO level, and expression of iNOS gene in leydig cells. Materials and Methods:Adult male Wistar rats (n=36) were used for experiments in three groups. The experim...
متن کاملInducible Nitric Oxide Synthase Expression in Human Airway Epithelial Cells
Human respiratory epithelium expresses inducible nitric oxide synthase (iNOS) continuously in vivo, however mechanisms responsible for maintenance of expression are not known. We show that IFN g is sufficient for induction of iNOS in primary human airway epithelial cells (HAEC) in vitro, and IL-4 potentiates IFN g -induced iNOS expression in HAEC through stabilization of iNOS mRNA. IFN g /IL-4–...
متن کاملexpression of inducible nitric oxide synthase gene (inos) stimulated by hydrogen peroxide in human endothelial cells
inducible nitric oxide synthase (inos) gene expresses a calcium calmudolin-independent enzyme which can catalyse no production from l-arginine. the induction of inos activity has been demonstrated in a wide variety of cell types under stimulation with cytokines and lipopoly saccharide (lps). previous studies indicated that all nitric oxide synthases (nos) activated in human umbilical vein endot...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2003
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)63876-x